An enzyme necessary to turn testosterone into dihydrotestosterone, the hormone responsible for the development of male external genitalia in the foetus and some secondary sex characteristics in adulthood (namely, body hair, facial hair and prostatic development in males, and acne during adolescance.)

The gene for 5-alpha-reductase production is located on chromosome 5. Doctors are considering/exploring the development of a 5-alpha-reductase blocker for the treatment of baldness and prostate cancer.

Lack of 5-alpha-reductase production (during gestation and childhood) results in a form of being intersexed/pseudohermaphrodism) called, simply, 5-alpha-reductase deficiency.

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