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2,N-DIMETHYL-4,5-METHYLENEDIOXYAMPHETAMINE
SYNTHESIS: A mixture of 102 g POCl3 and 115 g N-
methylformanilide was
allowed to stand for 0.5 h at room tem
perature during which time it
turned a deep claret color. To this there was added 45 g
3,4-methylenedioxytoluene and the mixture was held on the steam bath
for 3 h. It was then added to 3 L H2O. Stirring was continued until
the oil which had separated had become quite firm. This was removed
by filtration to give a greenish, somewhat gummy,
crystalline solid,
which was finely ground under 40 mL MeOH and again filtered giving,
when air dried, 25 g of an almost white solid. Re
crystallization of a
small sample from
methylcyclopentane gave ivory-colored glistening
crystals of
2-methyl-4,5-methylenedioxybenzaldehyde with a mp of
88.5-89.5 °C. In the infra-red, the
carbonyl was identical to that of
the starting
piperonal (1690 cm-1) but the fingerprint was different
and unique, with bands at 868, 929, 1040 and 1052 cm-1.
A
solution of 23 g
2-methyl-4,5-methylenedioxybenzaldehyde in 150 mL
nitroethane was treated with 2.0 g
anhydrous ammonium acetate and
heated on the steam bath for 9 h. The excess
solvent was removed
under vacuum to give a dark yellow oil which was
dissolved in 40 mL
hot MeOH and allowed to
crystallize. The solids were removed by
filtration, washed modestly with MeOH and air dried, to give 21.2 g of
1-(2-methyl-4,5-methylenedioxyphenyl)-2-nitropropene as beautiful
yellow
crystals with a mp of 116-118 °C. Recrystallization of an
analytical sample from MeOH gave lustrous bright yellow
crystals with
a mp of 120-121 °C. Anal. (
C11H11NO4) C,H,N.
A suspension of 54 g
electrolytic elemental iron in 240 g glacial
acetic acid was warmed on the steam bath, with frequent stirring.
When the reaction between them started, there was added, a portion at
a time, a
solution of 18.2 g
1-(2-methyl-4,5-methylenedioxyphenyl)-2-nitropropene in 125 mL warm
acetic acid. The orange color of the
nitrostyrene solution became
quite reddish, white solids of iron
acetate appeared, and a dark
tomato-colored crust formed which was continuously broken back into
the reaction mixture. Heating was continued for 1.5 h, and then all
was poured into 2 L H2O. All the in
solubles were removed by
filtration, and these were washed well with
CH2Cl2. The filtrate and
washes were combined, the
phases separated, and the aqueous phase
extracted with 2x100 mL additional
CH2Cl2. The combined organics were
washed with 5%
NaOH, and the
solvent removed under vacuum. The
residue weighed 15.9 g, and was
distilled at 90-110 °C at 0.4 mm/
Hg to
give 13.9 g of
2-methyl-4,5-methylenedioxyphenylacetone that
spontaneously
crystallized. A small sample from
methylcyclopentane
had a mp of 52-53 °C, another from hexane a mp of 53-54 °C, and
another from MeOH a mp of 54-55 °C. Anal. (
C11H12O3) H; C calcd,
68.73; found 67.87, 67.84.
To a stirred
solution of 30 g
methylamine hydrochloride in 200 mL warm
MeOH there was added 13.5 g
2-methyl-4,5-methylenedioxyphenylacetone
followed, after returning to room tem
perature, by 7 g
sodium
cyanoborohydride. There was added HCl as needed to maintain the
pH at
approximately orange on external damp universal
pH paper. After a few
days, the reaction ceased generating base, and all was poured into 2 L
dilute H2SO4 (caution, HCN evolved). This was washed with 3x75 mL
CH2Cl2, made basic with 25%
NaOH, and the resulting mixture extracted
with 3x100
CH2Cl2. The pooled extracts were stripped of
solvent under
vacuum and the residue, 15 g of a pale amber oil, was
distilled at
95-110 °C at 0.4 mm/
Hg. There was obtained 12.3 g of a white oil that
was
dissolved in 60 mL IPA, neutralized with approximately 5.5 mL
concentrated HCl, and
crystals of the salt formed spontaneously.
These were loosened with the addition of another 10 mL IPA, and then
all was diluted by the addition of an equal volume of
anhydrous Et2O.
The white
crystals were separated by filtration,
Et2O washed, and air
dried to give 14.1 g of 2,N-
dimethyl-4,5-
methylenedioxyamphetamine
hydrochloride (M
ADAM-6) as a brilliant white powder with a mp of
206-207 °C. Anal. (
C12H18ClNO2) C,H.
DOSAGE: greater than 280 mg.
DURATION: unknown.
QUALITATIVE COMMENTS: (with 180 mg) There is a hint of good things
there, but nothing more than a hint. At four hours, there is no
longer even a hint.
(with 280 mg) I took 150 milligrams, waited an hour for results,
which was niente, nada, nothing. Took supplements of 65 milligrams
twice, an hour apart. No effect. Yes, we giveth up.
EXTENSIONS AND COMMENTARY: The structure of M
ADAM-6 was designed to be
that of
MDMA, with a
methyl group attached at what should be a
reasonably indifferent position. In fact, that is the genesis of the
name.
MDMA has been called
ADAM, and with a
methyl group in the
6-position, M
ADAM-6 is quite understandable. And the other
ortho-position is, using this
nomenclature, the 2-position, and with a
methyl group there, one would have M
ADAM-2. I should make a small
apology for the choice of numbers.
MDMA is a
3,4-methylenedioxy
compound, and the least ambiguous numbering scheme would be to lock
the
methylenedioxy group inescapably at the
3,4-place, letting the
other ring position numbers fall where they may. The rules of
chemistry ask that if something is really a
3,4,6-orientation it
should be renumbered as a
2,4,5-orientation. Let's quietly ignore
that request here.
How fascinating it is, that a small
methyl group, something that is
little more than one more minor bump on the surface of a molecule that
is lumpy and bumpy anyway, can so effectively change the action of a
compound. A big activity change from a small structure change usually
implies that the bump is at a vital point, such as a target of
metabolism or a point of critical fit in some receptor site. And
since 6-M
ADAM can be looked upon as 6-bump-
MDMA, and since it is at
least 3x less potent than
MDMA, the implication is that the action of
MDMA requires some unbumpiness at this position for its particular
action. There are suggestions that the body may want to put a
hydroxyl group right there (a 6-hydroxy-dop
amine act), and it couldn't
if there was a
methyl group right there. The
isopropylamine side
chain may want a certain degree of swing-around freedom, and this
would be restricted by a
methyl bump right next to it. And there are
all kinds of other speculations possible as to why that position
should be open.
Anyway, M
ADAM-6 is not active. And the equally intriguing positional
isomer, the easily made M
ADAM-2, will certainly contribute to these
speculations. A quiz for the reader! Will
2,N-
dimethyl-
3,4-methylenedioxyamphetamine (M
ADAM-2) be: (1) Of much
reduced activity, akin to M
ADAM-6, or (2) Of potency and action
similar to that of
MDMA, or (3) Something unexpected and
unanticipated? I know only one way of finding out. Make the Schiffs'
base between
piperonal and
cyclohexylamine, treat this with butyl
lithium in hexane with some TMEDA present, add some
N-
methylformanilide, convert the formed
benzaldehyde to a
nitrostyrene
with
nitroethane, reduce this with elemental iron to the
phenylacetone, reduce this in the presence of
methylamine with
sodium
cyanoborohydride, then taste the result.
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