AKA:
WHS
AKA: Wolf Syndrome
AKA:
4p- Syndrome
AKA: Deletion of the
Short Arm of the
Fourth Chromosome.
Cause:
WHS is caused by the deletion of the short arm of the fourth chromosome. The amount of material deleted may range from about 50% of the short arm to a small break that can't be detected by normal
chromosome analysis. Because of the wide range of deleted material (1% to 50%), the effect on each child varies widely.
Possible Symptoms (Varies with the %deleted):
severe
growth problems
mental retardation
microcephaly
"
Greek Helmet" faces
cleft lip or
palate
coloboma of the
eye
cardiac septal defects
various other physical
disabilities
More Information: www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?194190