In times past, an extract of Belladonna (the plant) was used by Belladonnas (the human variety) in times past as eyedrops.

This was done as part of their makeup preparations. The atropine content of the fluid had the effect of dilating the pupil, thus making their eyes supposedly more attractive. It had the side effect of making their vision a little blurry and make their heart rates go up ever so slightly but that was little price to pay for big dilated pupils or so it seemed.

Dilated pupils are considered more attractive because pupils normally dilate when a person is aroused ...