The KC-135 tanker aircraft is built on the U.S. Air Force's common -135 airframe. Any aircraft with -135 in its U.S. military designation (see Aircraft Designations) is built on the precursor to the Boeing 707 airframe. The large number of planes that share this base type makes for savings in common parts and maintenance tools, training and facilities. However, the 707 airframe is approaching forty years of age, and has not been manufactured in quite some time. Although there is a large pool of civilian airframes available used for remanufacturing or parts, the U.S. Air Force has begun moving its large-body platforms to the more widely available (and still manufactured) Boeing 747 base airframe. Aircraft built on this pattern carry the designation suffix 'C-25.' Air Force One is usually one of two VC-25 aircraft maintained and modified for the purpose of transporting the POTUS or other VIPs.

Some other aircraft that share the -135 designation: