One of the longest words in the Oxford English Dictionary (with one more letter than "antidisestablishmentarianism," which is often said to be the longest word), floccinaucinihilipilification is a term believed to have been coined by Samuel Coleridge (of Ancient Mariner fame). The word literally means "to underestimate the importance of something because of its small size."
In stark contrast to this long, drawn-out word is Samuel Beckett's Breath, a play that lasts less than a minute and consists primarily of the sounds of a baby crying, inhalation, and exhalation. I mention this dichotomy because the word and the play are, ironically, linked by an academic paper published by University of Alabama at Birmingham professor (and Beckett scholar) William Hutchings. The paper, entitled "Samuel Beckett's Breath: An Antifloccinaucinihilipilificationistical View," details the subtle nuances of Beckett's play in 100+ pages. As a result, the longest word is used in the title of the longest literary work ever to address the shortest play. (Insert rim shot here.)