Obeah is also, in Vampire: The Masquerade, the unique discipline of the Healer branch of the Salubri bloodline. It helps those goody-goody Salubri heal the sick and insane. Obeah can perform miracles such as granting relief from all pain, healing aggravated damage instantaneously, and even helping someone recover their sanity (in game terms, it can remove derangements -- however, doing so requires the practitioner to remove the patient's soul for a brief period, which is what allowed Clan Tremere to give the Salubri their reputation as soul-stealing infernalist monsters). In order to use most Obeah powers higher than level 2, the third eye that all Salubri have in their foreheads must open. Out of this eye, a beautiful golden light shines.

Obeah is closely related to Valeren, which is the unique discipline of the Warrior branch of the Salubri.