The Brain's ongoing goal, which he only met once or twice, but it was always taken away from him again. I'm referring, of course, to Pinky and The Brain, a Warner Bros. cartoon spun-off of Animaniacs based on one insane lab mouse and one hell-bent on world domination.

Pinky: What are we going to do tomorrow night, Brain?
Brain: The same thing we do every night, Pinky: Try to take over the world!