The Roman Empire is generally very tolerant of religions that differ from the Roman religion (which incorporates emperor worship as well as the Gods). For example, warlike Persian religions were very popular among Roman soldiers. The Egyptian religion was allowed to be practiced freely. However, since the introduction of Christianity, Christians were persucted for refusing to acknowledge the deity of the Roman empire.

Christians were persecuted for their belief in a single God. Among the more popular methods of execution was the feeding of Christians to lions at the circus, or groups being massacred by gladiators for sport. Crucifixion was another popular method, as was immolation.

The executions came on and off as time passed. It was not until the end of the Roman empire when Constantine the Great converted to Christianity did the persecution of Christians fully end.