Mexico City neighborhood famous for the 1968 massacre of protestors. At the Plaza de las Tres Culturas, a protest for human rights and a true democracy in Mexico turned bloody. The Mexican army surrounded the protestors and began to shoot unrepentantly into the crowd. Government officials claimed only approximately three dozen deaths, but most Mexicans do not accept any figure under one hundred, while many believe that anywhere from three to five hundred were massacred there.

It is also the name place of one of the cities annexed by the Mexica or Aztec Empire. Once integrated into Tenochtitlán, it served as the Aztec capital's market district. It was also the site of the massacre of tens of thousands of Aztecs during the final days of the Aztec Empire (August 13-18, 1521).