The phrase 'at home' is generally synonymous with 'comfortable'.

Consider the following examples:

...And there were the new tenants who ... were so much at home there now that he would hardly have to guess ... what ultimate insolence would soon be theirs.   --   Edwin Arlington Robinson's The New Tenants
"That is impossible. You know nothing about whereness. The only way to come to know where you are is to begin to make yourself at home."   --   George MacDonald's Lilith
@home (pronounced 'at home') is also a trademark of At Home Corporation, a broadband internet provider.

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