The nemesis of Calvin from the Calvin and Hobbes comic strip. A serious girl who wants to play house instead of playing something as weird as Spaceman Spiff. Hobbes doesn't seem to have nearly as big a problem with her as Calvin does.

The girl character in the comic strip Calvin and Hobbes. She is described by the creator, Bill Watterson as "earnest, serious and smart - the kind of girl I was attracted to in school and eventually married". *Derkins* is Watterson's wife's family's beagle's nickname.
Calvin is always trying to annoy Susie... like by forming the club: G.R.O.S.S. = Get Rid Of Slimy girlS.

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