A replisome is any of the sites on the matrix of a cell nucleus that contains enzyme complexes in which DNA replication occurs. It is located at the replication fork, and consists of two DNA polymerases III enzymes (one for each strand) and a primosome.

Wolford, Leah. "Mechanics of DNA Replication." Hanover College. Science Center, Hanover. 6 October 2004.

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