Because peyote contains a lot of weird alkaloids it creates severe gastrointestinal distress upon ingestion. A peyote enema avoids the gastric upset. Chop up and mash (either with a mortar and pestle or in a blender with water) raw peyote buttons. Add water. Insert this slurry in the anus, preferably with a douche bag or if you have to, use turkey basters. Stand on your head to hold it in.

Usually, the participants will pay someone to be the insertor and/or anal attendant at a peyote enema party, as it is difficult to perform an enema on oneself.