the most common prefix to keyboard shortcuts that are sequences in Emacs. In my version of emacs (NTEmacs, 20.3.1), there are 174 key bindings that are prefixed by C-x, 90% of which, I have probably never even heard of, much less used...

if you correspond with an emacs user for a very long time over email, you will undoubtedly see this, and it's sibling, M-x used many a time.

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