This is a recipe from PiHKAL
. If you're interested in how the hardlinks
were chosen, read noding PiHKAL for Everything2
A stirred solution
of 9.0 g
(see the recipe for J for its
preparation) in 150 mL MeOH was treated with 9.0 g ethylamine
, 4.0 g anhydrous
NaOAc, and 3.0 g sodium
. The pH
was maintained between 6 and 7 by the
periodic addition of HCl. After the base formation had stabilized,
there was added an additional 9.0 g ethylamine hydrochloride
, 9.0 g
NaOAc and 2.0 g sodium cyanoborohydride
. With continuous stirring,
there was HCl added over the course of 1 h until the final pH
approximately 2. The reaction mixture was poured into 700 mL dilute
, and extracted with 3x75 mL CH2
Cl2. These extracts were pooled,
and back-extracted with dilute H2SO4. This was washed with 2x50 mL
Cl2, then made basic with dilute NaOH
and extracted with 2x75 mL
Cl2. Removal of the solvent
under vacuum gave a 0.81 g residue
which was dissolve
d in 10 mL IPA. Neutralization with concntrated HCl
formed white crystal
s spontaneously. These were diluted with Et2O
washed and air dried to provide 0.85 g
(ETHYL-J), with mp of 176-177 °C. Anal. (C13H20ClNO2
) C,H. The
neutral fraction that remained in the organic phase
acid extraction, was recovered by removal of the
under vacuum. There was obtained about 5 g of an amber liquid
that was largely 2-hydroxy-1-(3,4-methylenedioxyphenyl)butane
greater than 90 mg.
(with 65 mg) Perhaps aware at 20 minutes.
Definitely aware at 45 minutes. Diffusing to nothing at 3-4 hours.
(with 90 mg) I am somewhere between 1 and +. And everything became
lost in the evening with a couple of glasses of wine and talk that
went on to 3 AM.
EXTENSIONS AND COMMENTARY:
And nothing higher has ever been looked at.
If the analog
y with the amphetamine
counterparts (J with MDA
, and this, with MDE
) were to hold up (a drop of about a
third in potency with the lengthening of the chain by a carbon
one might guess that this compound would be an interesting intoxicant,
but probably not until you got up into the area at or above a 200
milligram dose. And that is a lot of chemical for the body to have to
handle. Some day, maybe.
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