If you're flying internationally, do your best to go either Business Class or First Class. Flying from San Francisco to Hong Kong, Taiwan or Japan can be a boring flight. With the upgraded facilities, you'll be more comfortable and the food is better (I had four complete filet mignon dinners on my last San Francisco-to-Hong Kong flight). Get up once an hour and walk for a bit. If it is a 747 or higher jet, go upstairs to the lounge. Bring music (I recommend a minidisc player) and a laptop with a power adapter.
One of the hazards of long-haul flights is that due to the extended periods of time spent in cramped conditions, deep vein thrombosis (DVT) can kick in (as mentioned by Rancid Pickle). Recent research has proved that this is far less likely to happen if you take an asprin before takeoff. This has the effect of thinning the blood and so reducing the chances of a blood clot forming (stroke victims take it for the same reason). This research has been taken so seriously that many airlines (including British Airways and Qantas) are soon to start handing out these pills prior to flights.
Regarding some of the other writeups in this node pertaining to alcohol consumption on planes. Personally I don't drink during flights as it gives me a huge headache and worsens my already screwed up sleep patterns, but if you decide to have a couple be very careful, as your alcohol tolerance plummets (due in part to the reduced oxygen levels in the cabin atmosphere), and being drunk on a aeroplane is illegal and you can easily get arrested... not a good way to start a holiday.
About half an hour after adding this writeup, I was reading New Scientist website, which had an article about DVT. It mentions the fact that some geneticists are suggesting that people be tested for a mutation in a gene called 'Factor V Leiden' which is related to blood clotting. The mutation occurs in about 1 in 20 people, but shows up in almost 50% of people hospitalised due to deep vein thrombosis caused by long haul flights. The article suggests that if people with this mutation could be picked out they could recieve extra water, and blood thinning drugs from the airlines.
On the first of many trips to and from Microsoft (from Hartford to Seattle), I bought myself a Gameboy Color. That was one of the best purchases I've ever made. It usually lasts many hours on a charge, and with a game such as Pokémon (where you can sink many hours into it), you can find yourself at your destination quickly. While there are medical problems to flying (as Rancid_Pickle) mentioned above, there are other considerations that you would like to take in mind, to keep your flight (even short ones) as humane as possible. There are both boredom and physical considerations to cope with.
Trust me on the gum. You'll thank me later.
1. The thing that got me from Montreal to Melbourne and back with little or no pain was a tiny pill available at most travel and health food stores called "No Jet-Lag." This is a homeopathic preparation and you have to take a pill every 2 hours, but I swear it works. It helps to prevent jet-lag and the bonus is that it makes you feel very sleepy and entirely relaxed. I'm a medical doctor and don't usually believe in or endorse this stuff, but I'm telling you, it's pure gold.
2. Sensory deprivation: bring a pair of earplugs, an eye mask, and an inflatable pillow for comfort (they always run out of the tiny, flat, white synthetic ones, anyway).
3. DVTs or deep vein thrombosis: this is basically what happens when blood clots form in the lower legs or more rarely, the pelvis. The clots themselves can cause swelling, pain and local redness, but the real danger is when they break off into the circulation ("embolize")and lodge in distant organs. The most common site is the lungs, producing a potentially fatal condition known as a pulmonary embolism. It would be virtually impossible to get a stroke from these blood clots, as they are in the venous system, not the arterial one, but I digress...
4. Air New Zealand is the best airline to fly to the Pacific Rim and beyond. The stewardesses are gorgeous, the seats recline all the way, the headrests are moveable and the dishes and cutlery are REAL.
5. Oh, yeah, and avoid EtOH and caffeine and drink lots of H2O.
Ever so often or maybe just once in a while you find yourself on a long flight. This can very often be an unpleasant experience, regardless of your destination. Usually going home is worse, probably since you're not traveling to something, just from. And then there's jet lag. This brief guide is an attempt to provide some hints and tips in order decrease the stress you might feel when traveling. Most of these are time saving steps before the actual flight. I've done a fair amount of business traveling. I've also done a fair amount of leisure traveling, but because of the former, the latter is usually not by air. I use my frequent flyer miles for upgrades instead of award travel, since the monopolistic and non-service oriented airlines have an intricate system of restrictions (blackout dates etc) in order to keep their frequent flyers from using their award miles.
Now. "Long" is of course a loose term, but more than 6 hours in the air I think is a fairly acceptable definition of a long trip for most people. A 6 hour flight usually mean that the total travel time is much longer, since there are more things to factor in than just the flight time:
Well now, what can you do about this ? There are basically three significantly different parts of the trip, and I will give you some tips for how to deal with them. The parts are Getting to the airport, At the airport and In the air