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telomerase
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Fri Jan 21 2000 at 19:30:00
A
reverse transcriptase
that lengthens a structure called the
telomere
. It consists of a
protein
component and an
RNA
component. The RNA component has been patented by
Geron Corporation
, U.S. Patent No. 5,583,016. To the extent that shortening of the telomere is responsible for
programmed cell death
, telomerase can be said to convey cellular immortality.
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CrazyIvan
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Tue Apr 04 2000 at 5:27:11
Note that
mice
, which are very short-lived and
cancer
prone, express telomerase in
all
the
cell
s of their body. In humans, telomerase is only expressed in 2 places, the
gonads
and in cancer cells. This enzyme, therefore, is a promising target for a
cure for cancer
.
(
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Fluffy The Cat
(1.8 y)
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Wed May 30 2001 at 18:56:34
Inhibition
of telomerase has been attempted as an anti-
cancer
therapy by insertion of
antisense rna
into cancer cells. In the early stages of cancer, this proves effective - the
telomeres
shorten sufficiently that
p53
is activated and
apoptosis
is initiated. However, cancer cells generally lose p53 functionality as they become more
malignant
. Once p53 activity has been lost, inhibiting telomerase doesn't induce apoptosis. Instead, you start losing the ends of your
chromosome
s. The chromosomal
instability
that ensues actually makes matters worse, and the
tumour
develops more quickly and becomes significantly more
nasty
. As a
cure for cancer
, telomerase inhibition leaves something to be desired but could be useful if the cancer is noticed soon enough.
printable version
chaos
telomere
RNA world
protein classification
reverse transcriptase
ATP synthase
p53
cure for cancer
Geron Corporation
immortality
apoptosis
protein
docetaxel
Cancer
gonad
Shylock
malignant
antisense RNA
Syncytium
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