In biochemical reactions, this refers to a situation in which an enzyme is prevented from binding to its intended substrate as a result of the presence of another molecule which can change the shape of the enzyme, along with its active site, so that the enzyme can't bind to its intended target. The other molecule does this by binding to a part of the enzyme other than the active site. As a result, this type of enzyme inhibition cannot be reversed by increasing the amount of substrate in the reaction, as is the case with competitive inhibition.
From the BioTech Dictionary at http://biotech.icmb.utexas.edu/. For further information see the BioTech homenode.
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