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Protease Inhibitor
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Tue Apr 04 2000 at 7:49:26
Drugs usually used to combat
HIV
. The HIV genome contains a large sequence that is
transcribed
and
translated
all at once, then
cleave
d into smaller, functional
protein
s by a
protease
. These drugs block the protease from acting, so this large series of
gene
s remains as one long
polyprotein
inside the
cytoplasm
until it is eventually degraded.
Virus
particles do not form and infect other cells. Most effective when coupled with two
nucleoside analog
s such as
AZT
. This enzyme made such a useful target because it is a
novel
protein, unlike any others found in normal
eukaryotic
cells. This means very few, if any,
side effect
s.
printable version
chaos
Molecular Biology of HIV
protease
Severe acute respiratory syndrome
polypeptide
AZT
nucleoside analogs
Exactly old enough, exactly young enough
Glivec
What to say to HIV-AIDS skeptics
CD8 Antiviral Factor
oncogene
eukaryotic
April 28, 2002
antiviral medicine
Velcade
SOY doesn't make you strong?
Doctor Bong
June 6, 2004
transformation
cytoplasm
August 15, 2006
cleave
proteasome
Virus
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