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MDMA synthesis

created by tom f

(idea) by tom f (3.6 mon) (print)   ?   (I like it!) Mon Jun 25 2001 at 20:37:55

This is almost certainly illegal wherever you live, and is also dangerous. Don't do it, just consider it a lesson in practical organic chemistry. MDMA is desirable to many people, either for personal use, or for resale. It is also illegal. Many of the chemical precursors useful for making it are also illegal. Classicly, the easiest way to synth MDMA is;

       CH2-CH=CH2    
  ____/   
 /    \    
/(BENZ)\
\      /
 \____/
 /    \
O      O
 \     /
  \   /
   CH2

Safrole, from the sassafras tree, is isomerised using KOH to

       CH=CH-CH3    
  ____/   
 /    \    
/(BENZ)\
\      /
 \____/
 /    \
O      O
 \     /
  \   /
   CH2

Isosafrole, which can the be reacted with HBr to give;

       CH2-CHBr-CH3    
  ____/   
 /    \    
/(BENZ)\
\      /
 \____/
 /    \
O      O
 \     /
  \   /
   CH2

Which reacts, under pressure, with methylamine to give

       CH2    NH
  ____/   \  /  \
 /    \    CH    CH3
/(BENZ)\   |
\      /   CH3
 \____/
 /    \
O      O
 \     /
  \   /
   CH2

MDMA. This is not the best synthesis in terms of conditions, or yield, but it's by far the simplest.
However, safrole is now rather hard to get hold of, precisely because it is so easy to synth MDMA from it. It is however, possible for the imaginative chemist to prepare saffarole from easily available Oil of Cloves (Eugenol) or Oil of Nutmeg (Isoeugenol). In fact, one could even prepare these chemicals from cloves or nutmegs. From isoeugenol,

       CH=CH-CH3    
  ____/   
 /    \    
/(BENZ)\
\      /
 \____/
 /    \
O      OH
 \
  CH3

can, in soloution with CH2Cl2, be reacted with pyridine, to give;

       CH=CH-CH3    
  ____/   
 /    \    
/(BENZ)\
\      /
 \____/
 /    \
OH     OH
 

which can then be methylnated, with further CH2Cl2 (this time as a reagent), to give isosafrole. Or in other words, with rather easily available precursors, you can turn nutmegs into ecstasy.

(idea) by QXZ (2.8 d) (print)   ?   (I like it!) Mon Jun 25 2001 at 21:00:28

The availability of MDMA and LSD on the street, along with most of the other "alphanumeric drugs" (e.g. 2C-B, 2C-T-7, 4-Acetoxy-DiPT, 5-MeO-DiPT, 5-MeO-DMT, pretty much everything mentioned in PiHKAL and TiHKAL) means one thing:

Chemistry graduate students gone bad.

These drugs are NOT easy to make. A synthesizer must have extensive experience in highly complex chemical reactions, laboratory procedure, etc.

So, basically, there are a lot of very, very smart chemistry students out there who have found a fun way to supplement their income. Or pay off their loans.


printable version
chaos

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