There are exceptions, notably in the SF bay area, where a lack of parent interstates (only Interstate 80) combined with a plethora of interstates, means that the x80 routes don't always follow these rules. Indeed, several don't even intersect I-80!
Another major "error" is Interstate 238, again in the bay area. As described above, they had a hard time coming up with numbers for the local freeways in the area, so they simply turned what had been CA 238 into I-238. This highway is nowhere near where an Interstate 38 would be, if there were a I-38 in the first place!
There are other exceptions, but these are the most exceptional.
Note that this is the numbering system for the United States Interstate system, not the US Highway system. Interstates are called interstates, and are notated I-###, US highways are called US routes and are notated US-###. There is no consistent numbering system for the US highway system. For instance, US 1 runs more-or-less parallel to I-95 for much of its journey up the East coast.
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